Synthesis, spectral characterization, electrochemical, anti-microbial and DNA binding studies of new schiff base metal(II) complexes derived from Isoniazid and 2-(4-amino-phenyl)-2H-isoquinolin-1-one
Keywords:
Isonizaid, Antioxidant, Escherichia Coli, Staphylococcus Aureus, Klebsiella Pneumoniae, Proteus Mirabillis, mycobacterium Tuberculosis.Abstract
Novel complexes of Cu(II), Co(II), Zn(II) and Ni(II) with isoniazid derivative (derived from 2-(4-Amino-phenyl)-2Hisoquinolin-1-one and isoniazid) were synthesized and characterized by different analytical and spectral techniques
including elemental analysis, magnetic susceptibility measurements, molar conductivity, IR, 1H-NMR, 13C-NMR, UV-Vis.,
FAB Mass spectra, EPR, thermal analysis and DNA binding studies. The synthesized metal complexes exhibited notable
antibacterial activity against the organisms Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus
mirabillis and Salmonella typhii when compared with the standard antibiotic (Streptomycin). The ligand and its metal
complexes were examined for antioxidant activity and all the complexes showed favorable free radical scavenging activity.
Among the synthesized metal complexes, the copper complex manifested the highest activity.
