The Influence of Imidazoline Receptor Agonists on the Ophthalmoscopic and Morphometric Parameters in Retina in Simulated Retinal Ischemia-reperfusion

Abstract

Introduction: An important task of experimental and clinical pharmacology and ophtalmology is to find highly effective
drugs for correcting retinal ischemia.
Objective: Improving the pharmacological correction efficiency of the retinal ischemia-reperfusion with use the new
substances related to imidazoline receptor ligands.
Materials and methods: The retinal ischemia-reperfusion model in rats was used, in which an increase in intraocular
pressure is carried out by mechanical pressure to the front chamber of the eye for 30 min. The protective effects of the
studied imidazoline receptor ligands: sodium salt of C7070, potassium salt of C7070 were evaluated based on the results of
semi-quantitative assessment of the eye fundus condition during ophthalmoscopy and counting the specific number of
neuronal nuclei in the inner nuclear layer.
Results and Discussion: The most pronounced protective effect is demonstrated by potassium salt of C7070 in a dose of
10 mg/kg, which is expressed in reaching the target values of the semi-quantitative assessment of the eye fundus condition
and the specific number of neuronal nuclei in the inner nuclear layer. When the pathology is corrected with sodium salt of
C7070 in a dose of 10 mg/kg, the semi-quantitative assessment of the eye fundus condition in the group decreased by
71.4% (p < 0.05), specific number of neuronal nuclei in the inner nuclear layer increased by 74,6% (p < 0.05) compared
with the group without correction.
Conclusion: The obtained data give an experimental substantiation of the pharmacological correction possibility of retinal
ischemia-reperfusion by imidazoline receptor ligands.