Study of the Selective Phenolic Inhibitors of Arginase 2 Acute Toxicity

Abstract

Introduction: We have previously shown that the isolated arginase 2 inhibitors have a pronounced endothelioprotective
level. A strategy is proposed for the targeted search for isolated arginase 2 inhibitors among compounds of a phenolic
nature. Received 3 compounds, isolated arginase inhibitors 2. As a result of the study, the acute toxicity of the compounds
obtained was studied.
Objectives of the study: to substantiate the choice of a phenolic compound, a selective arginase 2 inhibitor, which has the
lowest acute toxicity among the compounds obtained.
Methods: The experiment was conducted on laboratory mice of both sexes. Substance administered intragastrically.
Observation of the animals was carried out for 14 days.
Results: Summarizing the data obtained, it can be concluded that, after intragastric administration to mice, the investigated
compounds of phenolic nature under laboratory ciphers KUD259, KUD972, KUD973 are slightly toxic.
Conclusion: As the main candidate for the drug, it is advisable to consider the compound KUD972, which showed the
highest LD50 values, and therefore has the lowest toxicity.