The Effect of Arginase II Selective Inhibitors on the Functional Parameters of Experimental Animals in ADMA–Like Preeclampsia
Keywords:
Preeclampsia, Arginase Inhibitors, Endothelial Dysfunction.Abstract
Introduction: Perinatal mortality rate and the rate of preterm birth (10-12%) in pregnant women with hypertensive
disorders far outweigh the corresponding values in women with physiological pregnancy. Despite such close attention
worldwide to this problem, today the number of this complication has no tendency to decrease.
Objective of the study: To study the protective effect of arginase II selective inhibitors KUD–974, KUD–975, KUD–259
on functional parameters in rats with ADMA–like preeclampsia.
Methods: The study was conducted in 140 female Wistar rats weighing 250-300 g.
Results: The analysis of the obtained in this experimental study results showed that a decrease in the activity of arginase
leads to an increase in the production of nitric oxide, which has a beneficial effect on vascular function.
Conclusion: Arginase II inhibitors are currently a promising group of drugs for the treatment of hypertensive conditions in
pregnant women.
