A Novel Preparation of Thyme Cream as Superficial Antimicrobial Treatment

Abstract

Thyme plant leaf oil was extracted after drying the selected plant parts using alcohol and by hydro distillation method using
Clevenger aperture extraction. To ensure purity of the extracted oil their content the extraction, chemical analysis by IR
spectrum and GC-MS were done.29 components were detected in Thymbraspicata essential oil. The components were
mainly 7 sesquiterpenes (20.30 %), 17monoterpenes (58.62 %). The major components identified in the essential oil of
Thymbraspicata was Carvacrol (63.65 %), Gamma terpinene (13.06 %), m- Cymene (69.74 %), Caryophyllene (2.77 %)
and Thymol (0.11 %).In addition, 44 components were present at less than 1%. Carvacrol compound were isolated and
identified by Infrared spectroscopy (IR) respectively. Cold preparation is a unique new technique with the help of mixed of
Sodium polyacrylateemulsion (SPE) with other constitute of cream and herbal extract of thyme in a few minutes. Prepare
mixture of cream and oil extracted from thyme leaves in six different formulas (F1, F2, F3, F4, F5 and F6) and evaluation of
the anti-effect of the product on the growth of some pathologic microbial in addition to physiological and chemical
properties stability test. The pH was in the appropriate range (a proximately 6 pH).The formulations showed good spread
ability, no evidence of phase separation and good consistency during this study period. It was found that the viscosity of the
cream increases when decreasing the rate of shear so the viscosity of creams is inversely proportional to rate of shear. The
creams were found to be stable during stability study according to ICH (International council for harmonisation) of
guidelines (40 ± 2 °C/ 75 ± 5 % RH) for 3 months. A better comparison of preparations was obtained from formula F5,
which included 0.8 volume of thyme oil for each volume of cream. From the present study it can be concluded that it is
possible to develop creams containing herbal extracts.