DUE of Aminoglycosides in Patients Admitted to ICU of the Shiraz Namazi Hospital

Abstract

Introduction: Inappropriate use of antimicrobial agents is one of the most important factors inducing antimicrobial
resistance as well as can prolong duration of hospitalization and increase patient mortality rate.
Methods: Aminoglycosides use pattern evaluated in a cross-sectional study at the ICU of namazi hospital. Guidelines for
Aminoglycosides use were approved by pharmacy and therapeutic committee and study criteria were developed to assess
several parameters involved in Aminoglycosides therapy, such as appropriateness of drug use, dosage, duration of therapy.
Clinical and para clinical parameters such as microbial culture and sensitivity, serum creatinine and clearance creatinine,
WBC count collected.
Findings: 95 patients were enrolled in this study, including 50 male and 45 female patients. In most of patients [64%]
origin of infection was community and only in 36% of patients, hospital was source of infection. scores of
Aminoglycosides usage in Namazi hospital was calculated as 5.9 out of 11 and this means that in only 54% of cases
Aminoglycosides prescription was based on standard guideline.
Results: Clearly, considering the result of this study, in order to achieve appropriate treatment in patients and prevent toxic
effect. Using aminoglycoside standard guideline, serum level monitoring, according to microbiological datas and using
pharmacokinetic dosing method Are important and recommended.