Hepatic and Renal Status of Patients with Sickle Cell-β Thalassemia in Thi-Qar Province/Iraq

Abstract

The present study was designed to evaluate the biochemical parameters which related withthe hepatic and renal status in
sickle cell /β thalassemia patients. Patients with Hb S/β- Thal [n=100] 53 males and 47 females were on follow up in the
Thi-Qar Center for Hereditary Blood Disease, Thi-Qar province, Iraq who were included in this study and age and sex
matched healthy persons [n=50]as controls. The results showed that non-significant difference in a spartate transaminase
[AST], alkaline phosphate [ALP] and urea in sickle cell /β thalassemia patients compared with the control groups. Alanine
transaminase [ALT] and creatinine level decreased in sickle cell /β thalassemia patients compared with control, while,
Glomerular filtrate rate[GFR] increased in sickle cell /β thalassemia patients compared with the control. The result
showed non-significant difference between male and female in AST, ALT, ALP, urea and creatinine while increased
significant in male patients when compared with female patients. The study showed significant difference of AST, ALP,
urea, creatinine and GFR among age groups in patients with sickle cell /β thalassemia, while, there was non-significant
difference of ALT among age groups in patients with sickle cell /β thalassemia.