Effect of Isosorbide Dinitrate in Lipid Profile and Oxidant-Antioxidant Markers of Hypercholesterolemia Female Rats

Abstract

The present study aimed to investigate the effect of isosorbidedinitrate on lipid profile and oxidant-antioxidant markers of
hypercholesterolemia female rats. Twenty four adult female albino rats weighting 170-190 g were divided randomly into
four groups [six for each group], as follows: Group [1] : [Control group]: Rats were fed on standard diet and supplied with
tap water ad libitum for 30 days. Group [2] : [Cholesterol-treated group]: Rats were treated with daily high cholesterol diet
for 30 days. Group [3]: [ISDN-treated group]: Rats were administered a daily oral dose of ISDN [1.0 mg/kg BW dissolved
in 0.5 ml distill water] for 30 days. Group [4]: Rats were daily treated with [1 mg/kg dissolved in 0. 5 ml distill water] of
ISDN besides high cholesterol diet for 30 days. Serum total cholesterol, triglycerides, high density lipoprotein, low density
lipoprotein, very low density lipoprotein, malondialdehyde, albumin and reduced glutathione were determined. The results
showed a significant increase [P≤0.05] in the levels of total cholesterol, triglycerides, low density lipoprotein, very low
density lipoprotein and malondialdehyde; while there was a significant decrease in the levels of high density lipoprotein,
albumin and reduce glutathione in cholesterol treated group in comparison with control group. In addition, ISDN
administration caused a significant decrease in the levels of total cholesterol, triglycerides, low density lipoprotein, very
low density lipoprotein and malondialdehyde, with a significant increase in the levels of high density lipoproten, albumin
and reduced glutathionein group[4] in comparison with group[2].