Correlation between Serum Nitric Oxide Levels and Lipid Profile in Several Types of Arterial Occlusion in Atherosclerosis Cardiovascular Patients

Abstract

Objective: Cardiovascular disease[CVD] or Heart atherosclerosis is a chronic disease of the arterial wall associated with
inflammation and an imbalance in lipid metabolism, CVD increased with risk factors including high cholesterol, lowdensity lipoprotein [LDL] in the blood, low levels of high-density lipoprotein [HDL] in the blood, high blood pressure
[hypertension], tobacco smoke, diabetes, Obesity, lifeless lifestyle, age - family history of heart disease is also a risk factor
and uncontrollable factor. The study was designed to identify and compare lipid profile levels, NO in Atherosclerosis
disease and healthy individuals.
Materials and Methods: Nitric Oxide levels and Blood lipid profile were determined in 114 CVD divided into [38 of
single vessel disease] [SVD], [38 of [2 vessel disease]][2VD] and [38 of [3 vessel disease or complex]][3VD],and 114
healthy subjects, and comparing the concentration of [NO] with the rest of the biochemical parameters.
Results: Nitric Oxide and high-density lipoprotein[ HDL] levels in the blood showed a significant decrease in CVD
patients as compared to control group [ P ≤ 0.05 ].. while shown biochemical markers of blood lipid profile [serum TG,
TCH, LDL, VLDL] were showing significant increase in CVD patients as compared to control group [P ≤ 0.05], and the
results indicate a significant decrease in the concentration of nitric oxide [NO] and HDL in [3 vessel disease or complex]
[3VD]compared to [2 vessel disease][2VD], which in turn less than [single vessel disease][SVD] compared to the control
groups. The results showed a significant increase in the levels of lipid profile [TG , TCH , LDL, VLDL] in [3VD]
compared to [2VD], which in turn higher than [SVD].We also identified the correlation between [NO] and lipid profile and
the results showed a negative correlation between [NO]and [TG,TCH.LDL.VLDL] .and positive correlation between [NO]
and HDL.
Conclusion: In atherosclerosis, we find a significant reduction in levels of nitric oxide, and a significant rise in cholesterol
levels, triglycerides, LDL and VLDL during atherosclerosis and significant decrease in HDL level. Especially when the
type of occlusion increases [3VD], [2VD] and [SVD].