Study of LD50 and chronic toxicity of suspension of Silver nanoparticles size 50 nm in laboratory rats

Abstract

Antibiotic era is coming to the end, because of the wrong selecting of antibiotics and combination therapy and the mutation
skills of bacteria. In recent years, the use of nanosilver particles for therapeutic purposes has become more relevant. These
particles have an antibacterial effect and a fairly good effect on local inflammatory processes. We made suspension of
silver nanoparticles size 50 nm by the physic method and introduced into laboratory rats. Our studies demonstrates that
argentiumnano-particles can be administered in physical (non-chemical) pathways. It does not have LD50, however, its
consumption with high doses for prolonged period of time leads to histomorphological changes in healthy tissues.